A novel GABAergic dysfunction in human Dravet syndrome.
Gabriele RuffoloPierangelo CifelliCristina RosetiMaria ThomErwin A van VlietCristina LimatolaEleonora AronicaEleonora PalmaPublished in: Epilepsia (2018)
Our study indicates that a dysfunction of the GABAergic system, considered as a feature of brain immaturity, together with defective sodium channels, can contribute to a general reduction of inhibitory efficacy in Dravet brain, suggesting that GABAA receptors could be a target for new therapies.