FN1 mediated activation of aspartate metabolism promotes the progression of triple-negative and luminal a breast cancer.
Chen ChenLeiguang YeJinfeng YiTong LiuZhigao LiPublished in: Breast cancer research and treatment (2023)
Targeting the "FN1/YAP1/SLC1A3/Aspartate metabolism" regulatory axis provides a new target for BC diagnosis and treatment. This study also revealed that intratumoral metabolic heterogeneity plays an important role in the progression of different subtypes of breast cancer.