FN1 mediated activation of aspartate metabolism promotes the progression of triple-negative and luminal a breast cancer.

Chen ChenLeiguang YeJinfeng YiTong LiuZhigao Li

Published in: Breast cancer research and treatment (2023)

Targeting the "FN1/YAP1/SLC1A3/Aspartate metabolism" regulatory axis provides a new target for BC diagnosis and treatment. This study also revealed that intratumoral metabolic heterogeneity plays an important role in the progression of different subtypes of breast cancer.

Keyphrases

single cell
transcription factor
cancer therapy
young adults
childhood cancer