A case report of neuromyelitis optica spectrum disorder induced by pembrolizumab treatment for lung adenocarcinoma: a clinical and immunohistochemical study.

Shigeki HiranoAkira KojimaYoko NakayamaTakahiro TakedaTakashi KishimotoToshiyuki TakahashiSatoshi KuwabaraMasahiro Mori

Published in: BMC neurology (2022)

Immune checkpoint inhibitors may trigger AQP4+ NMOSD owing to their molecular similarity to AQP4 expressed in lung and glial tissues. Prompt brain/spinal cord imaging and anti-AQP4 antibody testing may facilitate early diagnosis of immune-mediated adverse event in central nervous system associated with immune checkpoint inhibitors.

Keyphrases

spinal cord
spectrum disorder
neuropathic pain
gene expression
spinal cord injury
advanced non small cell lung cancer
emergency department
cerebrospinal fluid
single molecule
tyrosine kinase