Manganese(II) promotes prebiotically plausible non-enzymatic RNA ligation reactions.

Ziwei LiuClancy Zhijian JiangAndrew D BondNicholas J ToscaJohn D Sutherland

Published in: Chemical communications (Cambridge, England) (2024)

Using different prebiotically plausible activating reagents, the RNA ligation yield was significantly increased in the presence of Mn(II). The mechanism of the activation reaction has been investigated using 5'-AMP as an analogue.

Keyphrases

nucleic acid
protein kinase
hydrogen peroxide
atomic force microscopy
room temperature
mass spectrometry