COVID-19 as a Trigger of Brain Autoimmunity.
Mayuri GuptaDonald F WeaverPublished in: ACS chemical neuroscience (2021)
Entry of SARS-CoV-2 into the central nervous system (CNS) activates microglia, triggering chronic neuroinflammation and possibly neurodegeneration. The complex transcriptome of SARS-CoV-2 shares molecular similarities with diverse human CNS protein epitopes, leading to a cytokine storm and various autoantibodies, potentially culminating in an autoimmune state. A COVID-19 initiated CNS autoimmune cascade may occur via multiple pathways including molecular mimicry, bystander activation, epitope spreading, production of autoantibodies, and immortalization of effector B-cells.
Keyphrases
- sars cov
- blood brain barrier
- respiratory syndrome coronavirus
- systemic lupus erythematosus
- multiple sclerosis
- endothelial cells
- cerebral ischemia
- drug induced
- coronavirus disease
- gene expression
- traumatic brain injury
- white matter
- single molecule
- dendritic cells
- neuropathic pain
- regulatory t cells
- lipopolysaccharide induced
- protein protein
- cerebrospinal fluid
- immune response
- brain injury
- small molecule
- spinal cord injury
- dna methylation
- celiac disease