Validation of a proteomic biomarker panel to diagnose minor-stroke and transient ischaemic attack: phase 2 of SpecTRA, a large scale translational study.
Andrew M PennMaximilian B BibokViera K SalyShelagh B CouttsMary L LesperanceRobert F BalshawKristine VotovaNicole S CroteauAnurag TrivediAngela M JacksonJanka HegedusEvgenia KlourfeldAmy Ying Xin YuCharlotte ZernaJayesh ModiPhilip A BarberGordon HoagChristoph H Borchersnull nullPublished in: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (2018)
Univariate analyses suggest insulin-like growth factor-binding protein 3 and serum paraoxonase/lactonase 3 are reliable and reproducible biomarkers for TIA status. Logistic regression models indicated L-selectin, apolipoprotein B-100, coagulation factor IX, and thrombospondin-1 to be significant multivariate predictors of TIA. We discuss multivariate feature subset analyses as an exploratory technique to better understand a panel's full predictive potential.