Utility of Sry-Related HMG-Box Gene 10 (SOX10) as a marker of melanoma in effusion cytology.

Josephine Kam Tai K DermawanDawn UnderwoodMaria Luisa C Policarpio-Nicolas

Published in: Diagnostic cytopathology (2019)

The sensitivity of SOX10 for melanoma in effusions is comparable with HMB45 with a 100% sensitivity. In terms of staining intensity, HMB45 appeared to be superior as it showed 100% moderate to strong intensity compared to 72% for SOX10. All four markers showed near-100% specificity in differentiating melanoma from nonmelanocytic malignant effusions. A combination of HMB45 and SOX10 might be useful as the initial stains of choice in diagnosing melanoma in effusion cytology.

Keyphrases

transcription factor
stem cells
high intensity
skin cancer
high grade
basal cell carcinoma
genome wide identification
computed tomography
magnetic resonance imaging
copy number
dna methylation
ultrasound guided
contrast enhanced