A novel Trichinella spiralis serine proteinase disrupted gut epithelial barrier and mediated larval invasion through binding to RACK1 and activating MAPK/ERK1/2 pathway.
Yan Yan SongXin Zhuo ZhangBo Ning WangYong Kang ChengXin GuoXi ZhangShao Rong LongRuo Dan LiuZhong Quan WangJing CuiPublished in: PLoS neglected tropical diseases (2024)
rTsSPc bound to RACK1 receptor in gut epithelium, activated MAPK/ERK1/2 pathway, decreased the expression of gut epithelial TJs proteins and disrupted the epithelial integrity, consequently mediated T. spiralis larval invasion of gut epithelium. The results are valuable to understand T. spiralis invasion mechanism, and TsSPc might be regarded as a vaccine target against T. spiralis invasion and infection.