Login / Signup

Palladium-catalyzed asymmetric [4+2] annulation of vinyl benzoxazinanones with pyrazolone 4,5-diones to access spirobenzoxazine frameworks.

Ben-Hong ChenShuai-Jiang LiuQian ZhaoQiumeng HouJia-Li YuanGu ZhanQian-Qian YangWei Huang
Published in: Chemical communications (Cambridge, England) (2023)
Herein, a palladium-catalyzed general synthetic strategy to access an attractive and decorated set of chiral spiro derivatives of benzoxazine compounds is unveiled utilizing vinyl benzoxazinanones reacted with pyrazolone 4,5-diones, which extends the application of vinyl benzoxazinanones with ketones. This asymmetric catalytic [4+2] cycloaddition reaction demonstrates a broad substrate scope with functional group tolerance in yields of up to 76% and up to 96% ee. A facile scale-up and straightforward conversion to diversely substituted products verify the synthetic utility of this method.
Keyphrases
  • reduced graphene oxide
  • quantum dots
  • highly efficient
  • solid state
  • ionic liquid
  • mass spectrometry
  • gold nanoparticles
  • capillary electrophoresis