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Pathogenic NF1 truncating mutation and copy number alterations in a dedifferentiated liposarcoma with multiple lung metastasis: a case report.

Yoon-Seob KimSun ShinSeung-Hyun JungYeun-Jung Chung
Published in: BMC medical genetics (2020)
Our results suggest that, in addition to the 12q13-15 amplification, NF1 inactivation mutation and other CNAs may contribute to DDLPS tumorigenesis accompanied by aggressive clinical features.
Keyphrases
  • copy number
  • mitochondrial dna
  • signaling pathway
  • lps induced
  • pi k akt
  • genome wide
  • nuclear factor
  • oxidative stress
  • dna methylation
  • inflammatory response
  • toll like receptor
  • immune response