Pathogenic NF1 truncating mutation and copy number alterations in a dedifferentiated liposarcoma with multiple lung metastasis: a case report.

Yoon-Seob KimSun ShinSeung-Hyun JungYeun-Jung Chung

Published in: BMC medical genetics (2020)

Our results suggest that, in addition to the 12q13-15 amplification, NF1 inactivation mutation and other CNAs may contribute to DDLPS tumorigenesis accompanied by aggressive clinical features.

Keyphrases

copy number
mitochondrial dna
signaling pathway
lps induced
pi k akt
genome wide
nuclear factor
oxidative stress
dna methylation
inflammatory response
toll like receptor
immune response