Bedaquiline for treatment of non-tuberculous mycobacteria (NTM): a systematic review and meta-analysis.

Shatha Omar Michael G WhitfieldMargaret B NolanJustice T NgomNabila IsmailRob M WarrenMarisa Klopper

Published in: The Journal of antimicrobial chemotherapy (2023)

Bedaquiline demonstrated strong antibacterial activity against various NTM species and is a promising drug to treat NTM infections. However, data on the genomic mutations associated with bedaquiline resistance were scarce, preventing statistical analyses for most mutations and NTM species. Further studies are urgently needed to better inform treatment strategies.

Keyphrases

drug resistant
multidrug resistant
electronic health record
big data
copy number
emergency department
genetic diversity
gene expression
case control
adverse drug
silver nanoparticles
artificial intelligence