The Genetic Basis of Apparently Idiopathic Ventricular Fibrillation - a Retrospective Overview.
Lisa M VerheulMartijn H van der ReeSanne A GroeneveldBart A MulderImke ChristiaansGijs F L KapelMarco AlingsMarianne BootsmaDaniela Q C M Barge-SchaapveldJippe C BaltSing-Chien YapIngrid P C KrapelsRachel M A Ter BekkePaul G A VoldersSaskia N van der CrabbenPieter G PostemaArthur A M WildeDennis DooijesAnnette F BaasRutger J HassinkPublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2023)
Almost all patients from the registry underwent, albeit not broad, genetic testing. The genetic yield of causal LP/P variants in idiopathic VF patients is 5%, increasing to 15% when including DPP6. In specific cases, the LP/P variant is the underlying diagnosis. A gene panel specifically for idiopathic VF patients is proposed.