High likelihood of actionable pathogenic variant detection in breast cancer genes in women with very early onset breast cancer.

Dafydd Gareth Evans Elke Maria van VeenHelen J ByersSarah J EvansGeorge Joseph Burghel Emma Roisin WoodwardElaine F HarknessDiana M EcclesStephanie L Greville-HaygateJamie M EllingfordNaomi L BowersMarta PereiraAndrew J WallaceSasha J HowellAnthony HowellFiona LallooWilliam G Newman Miriam Jane Smith

Published in: Journal of medical genetics (2021)

The rates of BRCA1, BRCA2 and TP53 PVs are high in very early onset breast cancer, with limited benefit from testing of additional breast cancer-associated genes.

Keyphrases

early onset
late onset
breast cancer risk
genome wide
gene expression
bioinformatics analysis
genome wide identification
dna methylation
sensitive detection