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Opening large-conductance potassium channels selectively induced cell death of triple-negative breast cancer.

Gina SizemoreSarah McLaughlinMackenzie NewmanKathleen BrundageAmanda AmmerKaren MartinElena PugachevaJames CoadMalcolm D MattesHan-Gang Yu
Published in: BMC cancer (2020)
Our results support the idea that hyperpolarization induced by opening BK channel in TNBC cells can become a new strategy for development of a targeted therapy in TNBC.
Keyphrases
  • cell death
  • cell cycle arrest
  • induced apoptosis
  • high glucose
  • diabetic rats
  • pi k akt
  • oxidative stress
  • drug induced
  • endoplasmic reticulum stress
  • signaling pathway
  • endothelial cells
  • cell proliferation
  • stress induced