Potential Therapeutic Application of Regulatory T Cells in Diabetes Mellitus Type 1.
Iwona Ben-SkowronekJoanna SieniawskaEmilia PachWiktoria WrobelAnna SkowronekZaklina TomczykIga RosolowskaPublished in: International journal of molecular sciences (2021)
The autoimmune reaction against the beta cells of the pancreatic islets in type 1 diabetes mellitus (T1DM) patients is active in prediabetes and during the development of the clinical manifestation of T1DM, but it decreases within a few years of the clinical manifestation of this disease. A key role in the pathogenesis of T1DM is played by regulatory T cell (Treg) deficiency or dysfunction. Immune interventions, such as potential therapeutic applications or the induction of the Treg-cell population in T1DM, will be important in the development of new types of treatment. The aim of this study was to evaluate innovative immune interventions as treatments for T1DM. After an evaluation of full-length papers from the PubMed database from 2010 to 2021, 20 trials were included for the final analysis. The analysis led to the following conclusions: Treg cells play an important role in the limitation of the development of T1DM, the activation or application of Tregs may be more effective in the early stages of T1DM development, and the therapeutic use of Treg cells in T1DM is promising but requires long-term observation in a large group of patients.
Keyphrases
- induced apoptosis
- end stage renal disease
- regulatory t cells
- glycemic control
- cell cycle arrest
- chronic kidney disease
- newly diagnosed
- physical activity
- multiple sclerosis
- oxidative stress
- type diabetes
- peritoneal dialysis
- emergency department
- single cell
- cell death
- cell proliferation
- electronic health record
- replacement therapy
- patient reported outcomes
- pi k akt
- smoking cessation