Login / Signup

Hemocompatibility of all-trans retinoic acid-loaded citrate polymer coatings for vascular stents.

Heather UrsinoBisheng ZhangChristopher LudtkaAntonio WebbJosephine B Allen
Published in: Regenerative engineering and translational medicine (2022)
This study demonstrates AtRA loaded POC coatings are hemocompatible, noninflammatory, and provide a promising strategy in enhancing vascular stent techniques and clinical integration. Possessing hemocompatibility and immunological compatibility that is at least as good as bare metal stents as clinical standards support the use of AtRA-POC coatings for vascular applications. Additionally, selectively reducing smooth muscle cell proliferation while supporting endothelial cell proliferation and migration further demonstrates the potential of these materials in significantly improving the state of vascular stent technology in the area of stent thrombosis and neointimal hyperplasia.
Keyphrases
  • smooth muscle
  • cell proliferation
  • drug delivery
  • pulmonary embolism
  • cell cycle
  • climate change
  • wound healing
  • signaling pathway
  • vascular endothelial growth factor
  • human health