Short- and Long-Term Effects on Glucose Control of Nonadherence to Insulin Therapy in People With Type 2 Diabetes An In Silico Study.

Roberto Visentin Claudio CobelliJochen SieberChiara Dalla Man

Published in: Journal of diabetes science and technology (2024)

Impaired adherence to MDI therapy in T2D leads to glucose control deteriorations in both short and long terms. Interestingly, short-term hyperglycemia seems being contrasted by residual endogenous insulin secretion, which statistically increased by 3-fold after delayed/skipped insulin boluses compared with optimal ones.

Keyphrases

type diabetes
glycemic control
blood glucose
molecular docking
metabolic syndrome
mesenchymal stem cells
insulin resistance
weight loss
molecular dynamics simulations