Treatment of pancreatic cancer with irreversible electroporation and intratumoral CD40 antibody stimulates systemic immune responses that inhibit liver metastasis in an orthotopic model.
Jayanth S Shankara NarayananTomoko HayashiSuna ErdemSara McArdleHerve TiriacPartha RayMinya PuZbigniew MikulskiAaron MillerKaren MesserDennis CarsonStephen SchoenbergerRebekah R WhitePublished in: Journal for immunotherapy of cancer (2023)
IRE can induce local tumor regression and neoantigen-specific immune responses. Addition of CD40Ab to IRE improved dendritic cell activation and neoantigen recognition, while generating a strong systemic antitumor T-cell response that inhibited metastatic disease progression.