Protein biomarkers GDF15 and FGF21 to differentiate mitochondrial hepatopathies from other pediatric liver diseases.

Johan L K Van Hove Marisa W Friederich Dana K Strode Roxanne A Van Hove Kristen R Miller Rohit Sharma Hardik Shah Jane Estrella Linda Gabel Simon Peter Horslen Rohit Kohli Mark A Lovell Alexander Gerhard Miethke Jean P Molleston Rene Romero James E Squires Estella M Alonso Stephen L Guthery Binita M. Kamath Kathleen M Loomes Philip Rosenthal Krupa R Mysore Laurel A Cavallo Pamela L Valentino John C Magee Shikha S Sundaram Ronald J Sokolnull null

Published in: Hepatology communications (2024)

GDF15 and FGF21 are significantly higher in children with MH compared to other childhood liver diseases and controls and, when combined, were predictive of MH and had prognostic implications.

Keyphrases

oxidative stress
young adults
binding protein
early life
small molecule