Tenofovir disoproxil fumarate directly ameliorates liver fibrosis by inducing hepatic stellate cell apoptosis via downregulation of PI3K/Akt/mTOR signaling pathway.

Sung Won LeeSung Min KimWonhee HurByung-Yoon KangHae Lim LeeHeechul NamSun Hong YooPil Soo SungJung Hyun KwonJeong Won JangSeong-Jun KimSeung Kew Yoon

Published in: PloS one (2021)

TDF directly ameliorates liver fibrosis by downregulating the PI3K/Akt/mTOR signalling pathway, which results in the apoptosis of activated HSCs. The antifibrotic effects of TDF indicate that it may be a therapeutic agent for the treatment of liver fibrosis.

Keyphrases

liver fibrosis
signaling pathway
cell proliferation
pi k akt
mouse model
oxidative stress
cell cycle arrest
endoplasmic reticulum stress
epithelial mesenchymal transition
antiretroviral therapy