Spiny keratoderma: Report of three cases.
Thales Pereira de AzevedoCelso Tavares SodréChristiana de Lima SantangeloDanielle Carvalho QuintellaTullia CuzziMárcia Ramos-E-SilvaPublished in: Journal of cosmetic dermatology (2019)
The authors discuss the epidemiologic data and differential diagnosis of spiny keratoderma, as well as the related literature. Associations with systemic disease or malignancy occur in some acquired cases. It is important to distinguish from other palmoplantar keratodermas as some of that can be linked to cutaneous and internal malignancies. To date, no cases of spiny keratoderma in patients with protein S deficiency and only one case of association with rectal carcinoma have been reported.