A multi-shell multi-tissue diffusion study of brain connectivity in early multiple sclerosis.
Carmen TurFrancesco GrussuFerran PradosThalis CharalambousCollorone SaraBaris KanberNiamh CawleyDaniel R AltmannSébastien OurselinFrederik BarkhofJonathan D ClaydenAhmed T ToosyClaudia Am Gandini Wheeler-KingshottOlga CiccarelliPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2019)
Connectivity-based nodal strength and network modularity are abnormal in the CIS. Furthermore, the increased network modularity observed in patients, indicating microstructural damage, is clinically relevant. Connectivity analyses based on multi-shell imaging can detect potentially relevant network changes in early MS.
Keyphrases
- white matter
- multiple sclerosis
- resting state
- functional connectivity
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- high resolution
- mass spectrometry
- oxidative stress
- lymph node
- peritoneal dialysis
- squamous cell carcinoma
- radiation therapy
- patient reported outcomes
- patient reported
- blood brain barrier
- subarachnoid hemorrhage
- brain injury