The sequence of regional structural disconnectivity due to multiple sclerosis lesions.

Ceren Tozlu Emily R Olafson Keith W JamisonEmily DemmonUlrike KaunznerMelanie MarcilleNicole ZingerNara MichaelsonNeha SafiThanh D Nguyen Susan A Gauthier Amy F Kuceyeski

Published in: bioRxiv : the preprint server for biology (2023)

MS lesion-related structural disconnections in the subcortex is an early biomarker for both disability and cognitive impairment in MS. PRL-related structural disconnection in the motor cortex may identify the patients at risk for moderate or severe disability in MS.

Keyphrases

multiple sclerosis
mass spectrometry
cognitive impairment
end stage renal disease
white matter
ms ms
newly diagnosed
ejection fraction
peritoneal dialysis
prognostic factors
early onset
high intensity
drug induced