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LuQi Formula Regulates NLRP3 Inflammasome to Relieve Myocardial-Infarction-Induced Cardiac Remodeling in Mice.

Xiaoqing ZhangDandan ZhaoJiling FengXiaoli YangZhenzhen LanTao YangXiaoni KongHui-Yan QuHua Zhou
Published in: Evidence-based complementary and alternative medicine : eCAM (2021)
LQF and perindopril significantly attenuated cardiac injury and apoptosis in the MI model. In addition, we found that LQF effectively inhibited the activation of the NLRP3/ASC/caspase-1/IL-1β cascade, decreased inflammatory infiltration, delayed ventricular remodeling, and downregulated caspase-3/Bax signaling, which can effectively reduce the apoptosis of cardiomyocytes. Perindopril showed the same mechanism.
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