PSPC1: a contextual determinant of tumor progression.

Published in: Molecular & cellular oncology (2020)

Protein-tyrosine kinase 6 (PTK6) sequestrated by its substrate paraspeckle component 1 (PSPC1) in nucleus is a tumor suppressor. PSPC1 functions as a contextual determinant of oncogenic subcellular translocations to synergize PSPC1/β-catenin and PTK6 tumorigenesis. Besides, PSPC1 C-terminal interacting domain (PSPC1-CT131), a dual inhibitor of PSPC1 and PTK6, suppresses cancer progression.

Keyphrases

tyrosine kinase
epidermal growth factor receptor
cell proliferation
papillary thyroid
epithelial mesenchymal transition
magnetic resonance imaging
transcription factor
young adults
small molecule
magnetic resonance
protein protein
long non coding rna
lymph node metastasis
dual energy
structural basis