Aberrant gene expression yet undiminished retinal ganglion cell genesis in iPSC-derived models of optic nerve hypoplasia.

Jennifer G AparicioHanno HoppNarine HarutyunyanCarly StewartDavid CobrinikMark Borchert

Published in: Ophthalmic genetics (2023)

ONH genetic background was not associated with impaired RGC genesis but was associated with DEGs exhibiting disease contribution potential. This constitutes some of the first evidence of a genetic contribution to ONH.

Keyphrases

optic nerve
gene expression
genome wide
dna methylation
copy number
single cell
optical coherence tomography
cell therapy
stem cells
mesenchymal stem cells
human health