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p16: cycling off the beaten path.

Raquel BujKatherine Marie Aird
Published in: Molecular & cellular oncology (2019)
p16INK4A (hereafter called p16) is a faithful cellular ally in the fight against tumorigenesis. Although its canonical pathway through retinoblastoma (RB) is well delineated, RB-independent functions for p16 are beginning to emerge. Here we summarize non-canonical roles of p16, including our recent finding on its role in nucleotide metabolism.
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