Improving performance of multigene panels for genomic analysis of cancer predisposition.

Brian H ShirtsSilvia CasadeiAngela L JacobsonMing K LeeSuleyman GulsunerRobin L BennettMargaret MillerSarah A Hall Heather HampelFuki M HisamaLorraine V NaylorCathleen GoetschKathleen LeppigJonathan F TaitSheena M ScrogginsEmily H Turner Robert LivingstonStephen J SalipanteMary-Claire KingTom WalshColin C Pritchard

Published in: Genetics in medicine : official journal of the American College of Medical Genetics (2016)

Individualized interpretation of gene panels is a complex medical activity. Interpretation by multiple experts in the context of personal and family histories maximizes actionable results and minimizes reports of VUS.Genet Med 18 10, 974-981.

Keyphrases

copy number
papillary thyroid
healthcare
squamous cell
genome wide
adverse drug
lymph node metastasis
gene expression
childhood cancer
genome wide identification
dna methylation
transcription factor