Biclonal lymphoproliferative disorders: another association with NOTCH1-mutated chronic lymphocytic leukaemias.
Helen FogartyAnita DowlingDavid O'BrienSteve LangabeerChristopher Laurence BaconRichard FlavinMichael O'DwyerBrian HennessyHilary O'LearyGerard CrottyRobert HendersonJames NolanPatrick ThorntonElisabeth VandenbergheFiona QuinnPublished in: Irish journal of medical science (2020)
In conclusion, we identified a significant (52%) incidence of NOTCH1 mutations in CLL in the context of biclonal LPD, associated with an indolent clinical course.