Tumor-targeting multi-shelled hollow nanospheres as drug loading platforms for imaging-guided combinational cancer therapy.
Wentao WangTao ZhengMing ZhangQicheng ZhangFan WuYihan LiuLin ZhangJun ZhangMingqian WangYi SunPublished in: Biomaterials science (2020)
In this work, we developed multi-shelled hollow nanospheres [RGD@am-ZnO@CuO@Au@DOX HNSs] as multifunctional therapeutic agents to achieve effective and targeted Zn2+/Cu2+ therapy, induced drug delivery under low pH/red-light conditions, and enhanced phototherapy under single red-light. The photothermal and photodynamic performance of am-ZnO@CuO@Au HNSs was enhanced relative to that of am-ZnO nanoparticles (NPs) or am-ZnO@CuO HNSs by utilizing the resonance energy transfer process and broad red-light absorption. The pH-sensitive am-ZnO@CuO@Au HNSs were dissolved to Zn2+/Cu2+ in the acidic endosomes/lysosomes of cancer cells, resulting in a cancer cell killing effect. The release performance of doxorubicin (DOX) from RGD@am-ZnO@CuO@Au@DOX HNSs was evaluated under low pH and red-light-irradiated conditions, and targeting of HNSs was confirmed by dual-modal imaging (magnetic resonance/fluorescence) of the tumor area. Moreover, in vivo synergistic therapy using RGD@am-ZnO@CuO@Au@DOX HNSs was further evaluated in mice bearing human pulmonary adenocarcinoma (A549) cells, achieving a remarkable synergistic antitumor effect superior to that obtained by monotherapy. This study validated that RGD@am-ZnO@CuO@Au@DOX HNSs can be a promising candidate for efficient postoperative cancer therapy.
Keyphrases
- cancer therapy
- reduced graphene oxide
- drug delivery
- quantum dots
- visible light
- sensitive detection
- energy transfer
- room temperature
- gold nanoparticles
- magnetic resonance
- high resolution
- endothelial cells
- induced apoptosis
- emergency department
- mass spectrometry
- mesenchymal stem cells
- drug release
- squamous cell carcinoma
- magnetic resonance imaging
- light emitting
- risk assessment
- pulmonary hypertension
- cell proliferation
- clinical trial
- cell death
- cell cycle arrest
- locally advanced
- metabolic syndrome
- computed tomography
- bone marrow
- molecularly imprinted
- induced pluripotent stem cells
- pi k akt
- contrast enhanced