Arginine catabolism metabolites and atrial fibrillation or heart failure risk: 2 case-control studies within the Prevención con Dieta Mediterránea (PREDIMED) trial.
Leticia GoniCristina RazquinEstefania Toledo-AtuchaMarta Guasch-FerreClary B ClishNancy Elvira Babio SánchezClemens WittenbecherAlessandro AtzeniA Heather EliassenLiming LiangCourtney DennisÁngel Alonso-GómezMontserrat FitóDolores CorellaEnrique Gómez-GraciaRamón EstruchMiquel FiolJose LapetraLluis Serra-MajemEmilio RosFernando ArósJordi Salas-SalvadóFrank B HuMiguel A Martínez-GonzálezMiguel Ruiz-CanelaPublished in: The American journal of clinical nutrition (2022)
Our results suggest that arginine catabolism metabolites could be involved in AF and HF. Interventions with the MedDiet may contribute to strengthen the inverse association between arginine and the risk of HF. This trial was registered at controlled-trials.com as ISRCTN35739639.