Joint polygenic and environmental risks for childhood attention-deficit/hyperactivity disorder (ADHD) and ADHD symptom dimensions.
Michael A MooneyPeter RyabininHannah MortonKatharine SelahRose GonoudMichael KozlowskiElizabeth NousenJessica TipsordDylan AntovichJoel SchwartzMegan M HertingStephen V FaraoneJoel T NiggPublished in: JCPP advances (2023)
Reproducible additive effects of PRS and family environment on ADHD symptoms were found, but GxE interaction effects were not replicated and appeared confounded by ancestry. Results highlight the potential value of combining exposures and PRS in clinical prediction algorithms. The observed differences in risks across ancestry groups warrant further study to avoid health care disparities.
Keyphrases
- attention deficit hyperactivity disorder
- human health
- autism spectrum disorder
- healthcare
- risk assessment
- working memory
- machine learning
- climate change
- air pollution
- deep learning
- genome wide association study
- young adults
- social media
- early life
- patient reported
- sleep quality
- childhood cancer
- health insurance
- life cycle