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Joint polygenic and environmental risks for childhood attention-deficit/hyperactivity disorder (ADHD) and ADHD symptom dimensions.

Michael A MooneyPeter RyabininHannah MortonKatharine SelahRose GonoudMichael KozlowskiElizabeth NousenJessica TipsordDylan AntovichJoel SchwartzMegan M HertingStephen V FaraoneJoel T Nigg
Published in: JCPP advances (2023)
Reproducible additive effects of PRS and family environment on ADHD symptoms were found, but GxE interaction effects were not replicated and appeared confounded by ancestry. Results highlight the potential value of combining exposures and PRS in clinical prediction algorithms. The observed differences in risks across ancestry groups warrant further study to avoid health care disparities.
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