Role of NADPH Oxidase in Metabolic Disease-Related Renal Injury: An Update.
Cheng WanHua SuChun ZhangPublished in: Oxidative medicine and cellular longevity (2016)
Metabolic syndrome has been linked to an increased risk of chronic kidney disease. The underlying pathogenesis of metabolic disease-related renal injury remains obscure. Accumulating evidence has shown that NADPH oxidase is a major source of intrarenal oxidative stress and is upregulated by metabolic factors leading to overproduction of ROS in podocytes, endothelial cells, and mesangial cells in glomeruli, which is closely associated with the initiation and progression of glomerular diseases. This review focuses on the role of NADPH oxidase-induced oxidative stress in the pathogenesis of metabolic disease-related renal injury. Understanding of the mechanism may help find potential therapeutic strategies.
Keyphrases
- metabolic syndrome
- chronic kidney disease
- oxidative stress
- endothelial cells
- high glucose
- induced apoptosis
- dna damage
- cell death
- end stage renal disease
- type diabetes
- insulin resistance
- risk assessment
- hydrogen peroxide
- nitric oxide
- adipose tissue
- cell cycle arrest
- cardiovascular disease
- ischemia reperfusion injury
- peritoneal dialysis
- endoplasmic reticulum stress
- human health
- climate change
- diabetic rats
- cardiovascular risk factors