Resveratrol promotes liver cell survival in mice liver-induced ischemia-reperfusion through unfolded protein response: a possible approach in liver transplantation.
Hamidreza TotonchiPooneh MokarramSaeed KarimaRamazan RezaeiRamazan RezaeiFarhad KoohpeymaShokoofe NooriNegar AzarpiraPublished in: BMC pharmacology & toxicology (2022)
The findings of this study suggest that hepatic ischemia occurs after liver transplantation and that receiving low-dose resveratrol treatment before reperfusion may promote graft survival through inhibition of UPR arms, especially PERK and IRE1α.
Keyphrases
- endoplasmic reticulum stress
- low dose
- high glucose
- acute myocardial infarction
- high dose
- endoplasmic reticulum
- cerebral ischemia
- diabetic rats
- high fat diet induced
- heart failure
- adipose tissue
- combination therapy
- acute ischemic stroke
- drug induced
- blood brain barrier
- binding protein
- acute coronary syndrome
- coronary artery disease
- insulin resistance
- endothelial cells