Phospho-ablation of cardiac sodium channel Nav1.5 mitigates susceptibility to atrial fibrillation and improves glucose homeostasis under conditions of diet-induced obesity.
Revati S DewalAmara Greer-ShortCemantha LaneShinsuke NirengiPedro Acosta ManzanoDiego Hernández-SaavedraKatherine R WrightDrew NassalLisa A BaerPeter J MohlerThomas J HundKristin I StanfordPublished in: International journal of obesity (2005) (2021)
These data demonstrate a novel role for CaMKII-dependent regulation of Nav1.5 in mediating susceptibility to arrhythmias and whole-body metabolism under conditions of diet-induced obesity.
Keyphrases
- insulin resistance
- weight loss
- metabolic syndrome
- atrial fibrillation
- high fat diet induced
- type diabetes
- catheter ablation
- weight gain
- left ventricular
- left atrial
- heart failure
- electronic health record
- adipose tissue
- left atrial appendage
- blood glucose
- skeletal muscle
- machine learning
- congenital heart disease
- direct oral anticoagulants
- radiation therapy
- acute coronary syndrome
- radiation induced
- venous thromboembolism
- data analysis
- glycemic control