TCF7L2 rs7903146 polymorphism association with diabetes and obesity in an elderly cohort from Brazil.

Lais BrideMichel Satya NaslavskyGuilherme Lopes YamamotoMarilia ScliarLúcia Helena Sagrillo PimassoniPaola Sossai AguiarFlavia de PaulaJaqueline WangYeda DuarteMaria Rita Passos-BuenoMayana ZatzFlávia Imbroisi Valle Errera

Published in: PeerJ (2021)

We confirmed that the rs7903146 is both associated with T2DM and obesity. The TCF7L2 rs7903146 T allele increased T2DM risk in the normal weight group and interacted with sex, age and BMI, while the C allele increased obesity risk. The TT genotype was associated with a lesser extent of BMI variation over the SABE study's 10-year period.

Keyphrases

weight gain
weight loss
type diabetes
insulin resistance
metabolic syndrome
body mass index
high fat diet induced
glycemic control
cardiovascular disease
physical activity
middle aged