Pathogenic Citrulline-Multispecific B Cell Receptor Clades in Rheumatoid Arthritis.

Philip J TitcombeGustaf WigerbladNatalie SipplNa ZhangAnna K ShmagelPeter SahlströmYue ZhangLaura O BarsnessYogita Ghodke-PuranikAzar BaharpoorMonika HanssonLena IsraelssonKarl SkrinerTimothy B NiewoldLars KlareskogCamilla I SvenssonKhaled AmaraVivianne MalmströmDaniel L Mueller

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2018)

Our findings suggest that broad ACPA specificities in RA arise from a restricted repertoire of evolving citrulline-multispecific B cell clades with pathogenic potential.

Keyphrases

rheumatoid arthritis
disease activity
ankylosing spondylitis
interstitial lung disease
systemic lupus erythematosus
high throughput sequencing
risk assessment
idiopathic pulmonary fibrosis