Endogenous α1-antitrypsin levels in the perilymphatic fluid correlates with severity of hearing loss.
Sabri El-SaiedHeike SchmittMartin DurisinBen-Zion JoshuaMuhammad Abu TailakhNils PrenzlerThomas LenarzDaniel M KaplanEli C LewisAthanasia WarneckePublished in: Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery (2020)
Insufficiency in α1-antitrypsin levels in the perilymph fluid of the inner ear appears to display a relationship with the severity of hearing loss. The prospect of introducing clinical-grade plasma-purified α1-antitrypsin directly onto the site of cochlear injury deserves thorough investigation.
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