Characteristic changes in plasma glutamate levels and free amino acid profiles in Japanese patients with type 1 diabetes mellitus.
Dan KawamoriYoko KageyamaTakayuki TanakaYuko IshizakaShigero HosoeNaoto KatakamiIichiro ShimomuraPublished in: Journal of diabetes investigation (2022)
Participants with type 1 diabetes showed characteristic changes in plasma glutamate levels and free amino acid profiles compared with controls and type 2 diabetes patients. Glucagon showed a closer correlation with amino acids than with parameters of glucose metabolism, suggesting that type 1 diabetes includes dysregulation in amino acids through dysregulated glucagon from remaining pancreatic α-cells, together with that in glucose by insulin deficiency.
Keyphrases
- amino acid
- type diabetes
- glycemic control
- end stage renal disease
- induced apoptosis
- ejection fraction
- newly diagnosed
- chronic kidney disease
- blood glucose
- insulin resistance
- prognostic factors
- cell cycle arrest
- blood pressure
- endoplasmic reticulum stress
- metabolic syndrome
- cell death
- cell proliferation
- skeletal muscle
- pi k akt