INHBA is Enriched in HPV-negative Oropharyngeal Squamous Cell Carcinoma and Promotes Cancer Progression.

Tsima Abou Kors Linda Hofmann Annika C Betzler Kathrina Payer Martin Bens Jens Truong Adrian von Witzleben Jaya Thomas Johann M Kraus Randa Kalaajieh Diana Huber Jasmin Ezić Julian Benckendorff Jens Greve Patrick J Schuler Christian Hermann Ottensmeier Hans Armin Kestler Thomas K Hoffmann Marie-Nicole Theodoraki Cornelia Brunner Simon Laban

Published in: Cancer research communications (2024)

Patients with HPV-negative OPSCC have a poorer prognosis due to distinct molecular pathways. This study reveals significant transcriptomic differences between HPV-negative and HPV-positive OPSCC, identifying INHBA as a key upregulated gene in HPV-negative OPSCC's oncogenic pathways. INHBA is crucial in promoting EMT, cell proliferation, and an immunosuppressive tumor environment, suggesting its potential as a therapeutic target for HPV-negative OPSCC.

Keyphrases

high grade
squamous cell carcinoma
cell proliferation
cervical cancer screening
copy number
single cell
rna seq
pi k akt