New strategies for confirmatory testing of secondary hypotheses on combined data from multiple trials.

Marc VandemeulebroeckeDieter A HäringEva HuaXiaoling WeiDong Xi

Published in: Clinical trials (London, England) (2024)

Inference on combined data across trials is a useful approach for generating pivotal evidence of efficacy for important but sample size-intense secondary endpoints. It requires careful preparation and regulatory discussion.

Keyphrases

electronic health record
big data
transcription factor
machine learning
molecularly imprinted
mass spectrometry
tandem mass spectrometry