Blockades of effector T cell senescence and exhaustion synergistically enhance antitumor immunity and immunotherapy.

Xia LiuFusheng SiDavid BagleyFeiya MaYuanqin ZhangYan TaoEmily ShawGuangyong Peng

Published in: Journal for immunotherapy of cancer (2022)

These studies prove the novel concept that targeting both effector T cell senescence and exhaustion is an effective strategy and can synergistically enhance cancer immunotherapy.

Keyphrases

regulatory t cells
dna damage
endothelial cells
dendritic cells
type iii
stress induced
cancer therapy
case control
immune response
drug delivery