A Wrong Fate Decision in Adipose Stem Cells upon Obesity.
Yiu-Ming CheungChui Yiu Bamboo ChookHoi-Wa YeungFung-Ping LeungWing-Tak WongPublished in: Cells (2023)
Progress has been made in identifying stem cell aging as a pathological manifestation of a variety of diseases, including obesity. Adipose stem cells (ASCs) play a core role in adipocyte turnover, which maintains tissue homeostasis. Given aberrant lineage determination as a feature of stem cell aging, failure in adipogenesis is a culprit of adipose hypertrophy, resulting in adiposopathy and related complications. In this review, we elucidate how ASC fails in entering adipogenic lineage, with a specific focus on extracellular signaling pathways, epigenetic drift, metabolic reprogramming, and mechanical stretch. Nonetheless, such detrimental alternations can be reversed by guiding ASCs towards adipogenesis. Considering the pathological role of ASC aging in obesity, targeting adipogenesis as an anti-obesity treatment will be a key area of future research, and a strategy to rejuvenate tissue stem cell will be capable of alleviating metabolic syndrome.
Keyphrases
- stem cells
- insulin resistance
- high fat diet induced
- metabolic syndrome
- adipose tissue
- weight loss
- skeletal muscle
- type diabetes
- cell therapy
- weight gain
- signaling pathway
- single cell
- machine learning
- bone mineral density
- cardiovascular risk factors
- physical activity
- deep learning
- cell proliferation
- body mass index
- drug delivery
- high resolution
- current status
- oxidative stress
- molecularly imprinted
- liquid chromatography
- decision making
- replacement therapy
- cell fate
- drug induced