Epistasis between phenylethanolamine N-methyltransferase and β2-adrenergic receptor influences extracellular epinephrine level and associates with the susceptibility to allergic asthma.

Yang Yie SioSri Anusha MattaYu Ting NgFook Tim Chew

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2020)

Epistatic interaction between genetic variants from PNMT (rs876493) and ADRB2 (rs11168070) is associated with serum epinephrine level and the susceptibility of asthma. Our findings improved the current understanding of the genetic basis of this disease, while genotypic states of these SNPs may serve as potential biomarkers to predict susceptibility to the disease.

Keyphrases

chronic obstructive pulmonary disease
allergic rhinitis
lung function
genome wide
gene expression
copy number
binding protein