Prodromal X-Linked Dystonia-Parkinsonism is Characterized by a Subclinical Motor Phenotype.
Julia SteinhardtHenrike HanssenMarcus HeldmannAndreas SprengerBjörn-Hergen LaabsAloysius DomingoCharles Jourdan ReyesJannik PrasuhnMax BrandRaymond RosalesThomas F MünteChristine KleinAna WestenbergerJean Q OropillaCid DiestaNorbert BrüggemannPublished in: Movement disorders : official journal of the Movement Disorder Society (2022)
Our study unraveled balance and gait abnormalities in NMCs that preceded the onset of XDP. These findings demonstrate prodromal motor changes among NMCs who will develop XDP with a very high likelihood in the future. Gait abnormalities had a predictive value for the estimated age at onset highlighting the impact of genetic modifiers in personalized treatment in monogenic neurodegenerative disorders. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.