Estrogen-receptor status and risk of contralateral breast cancer following DCIS.
Natasha K StoutAngel M CroninHajime UnoElissa M OzanneMichael J HassettElizabeth S FrankCaprice C GreenbergRinaa S PungliaPublished in: Breast cancer research and treatment (2018)
This finding suggests that ER+ DCIS may represent a field effect that confers increased propensity for developing cancer across breast tissue, regardless of laterality. In contrast, ER- DCIS may represent an isolated local event. Given that the majority of DCIS is ER+, and only a minority of DCIS patients receive hormonal therapy, consideration of ER status may influence treatment and surveillance approaches.