Serum Lipidomic Screen Identifies Key Metabolites, Pathways, and Disease Classifiers in Crohn's Disease.

Romain Ferru-ClémentGabrielle BoucherAnik ForestBertrand BouchardAlain BittonSylvie LesagePhil SchummMark LazarevSteve BrantRichard H DuerrDermot P B McGovernMark SilverbergJudy H Chonull nullAshwin AnanthakrishnanRamnik J XavierJohn D RiouxChristine Des Rosiers

Published in: Inflammatory bowel diseases (2023)

Untargeted lipidomic analyses uncovered perturbations in the circulating human CD lipidome, likely resulting from multiple pathogenic mechanisms. Models using as few as 5 biomarkers had strong disease classifier characteristics, supporting their potential use in diagnosis or prognosis.

Keyphrases

endothelial cells
ms ms
high throughput
genome wide
gene expression
risk assessment
dna methylation
high resolution
single cell
high resolution mass spectrometry