Contrast enhancement predicting survival in integrated molecular subtypes of diffuse glioma: an observational cohort study.

Johann-Martin HempelCornelia BrendleBenjamin BenderGeorg BierMarco SkardellyIrina Gepfner-TumaFranziska EckertUlrike ErnemannJens Schittenhelm

Published in: Journal of neuro-oncology (2018)

In univariate analysis, the presence of gadolinium enhancement on preoperative MRI scans is an unfavorable factor for survival. Regarding the molecular subgroups, gadolinium enhancement is an unfavorable prognostic factor in gliomas with IDHwild-type and those with ATRX retention. However, in multivariate analysis only patient age, IDH1/2 mutation status, MGMT promoter methylation status, and WHO grade IV are relevant for predicting survival.

Keyphrases

contrast enhanced
prognostic factors
dna methylation
magnetic resonance imaging
computed tomography
free survival
gene expression
high grade
transcription factor
case report
single molecule
diffusion weighted imaging