A simple validated multi-analyte method for detecting drugs in oral fluid by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).
Yufang ZhengErik SparveMats BergströmPublished in: Drug testing and analysis (2017)
A UPLC-MS/MS method was developed to identify and quantitate 37 commonly abused drugs in oral fluid. Drugs of interest included amphetamines, benzodiazepines, cocaine, opiates, opioids, phencyclidine and tetrahydrocannabinol. Sample preparation and extraction are simple, and analysis times short. Validation showed satisfactory performance at relevant concentrations. The possibility of contaminated samples as well as the interpretation in relation to well-knows matrices, such as urine, will demand further study.
Keyphrases
- liquid chromatography tandem mass spectrometry
- ms ms
- simultaneous determination
- solid phase extraction
- high performance liquid chromatography
- tandem mass spectrometry
- ultra high performance liquid chromatography
- chronic pain
- pain management
- molecularly imprinted
- high resolution
- liquid chromatography
- drinking water
- drug induced
- mass spectrometry
- risk assessment