Bayesian genome-wide TWAS with reference transcriptomic data of brain and blood tissues identified 93 risk genes for Alzheimer's disease dementia.

Published in: medRxiv : the preprint server for health sciences (2023)

-eQTL data of brain and blood tissues with GWAS summary data to identify risk genes of AD dementia. The risk genes we identified provide novel insights into the underlying biological pathways implicated in AD dementia.

Keyphrases

genome wide
mild cognitive impairment
electronic health record
cognitive impairment
dna methylation
gene expression
big data
white matter
resting state
copy number
single cell
transcription factor
artificial intelligence
data analysis
deep learning
brain injury